Urinary N-acetyl-beta-glucosaminidase as index of renal toxicity
Oudart, N.; Marcher, K.; Lacour, B.; Boulu, R.G.; Guichard, C.
Toxicological European Research. Recherche Europeenne en Toxicologie 3(3): 149-151
1981
ISSN/ISBN: 0249-6402 PMID: 7281165 Document Number: 181754
Urinary excretion of N-acetyl-beta-D-glucosaminidase (NAG) has been studied in rats submitted to potentially nephrotoxic drugs (acetylsalicylic acid, gentamicin). Both drugs induced increase in NAG excretion which was reversible and dose-dependent. The date presented in this paper suggest that urinary NAG determination may have value as screening device for the study of nephrotoxic effects in experimental toxicology.
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