Metabolic effects of diuretics
Kewitz, H.; Weber, W.
Münchener Medizinische Wochenschrift 123(47): 1799-1802
1981
ISSN/ISBN: 0341-3098 PMID: 6796854 Document Number: 181703
Thiazide diuretics and loop-diuretics, often used for treatment of hypertension, interfere with various metabolic reactions: An increase of uric acid in plasma is a regular finding, but gout will not be caused, an elevation of plasma lipoproteins has been observed but did not proceed to pathological values, in a number of patients blood glucose has been raised but without producing diabetes mellitus. In general, these metabolic interference are of minor pathological significance. Special treatment for these side-effects are needed in a few cases only. The indicated use of thiazide diuretics should not be disregarded because of their effects on regulatory mechanisms of metabolism.