D-dimer levels for Risk Stratification in Patients with Suspected COVID-19 - a Prospective Observational Study
Jauslin, A.S.; Kellett, J.; Brabrand, M.; Simon, N.R.; Rueegg, M.; Twerenbold, R.; Osswald, S.; Bassetti, S.; Tschudin-Sutter, S.; Siegemund, M.; Rentsch, K.; Bingisser, R.; Nickel, C.H.
Acute Medicine 20(3): 193-203
2021
ISSN/ISBN: 1747-4892 PMID: 34679137 Document Number: 18170
Elevated D-dimer levels have been observed in COVID-19 and are of prognostic value, but have not been compared to an appropriate control group. Observational cohort study including emergency patients with suspected or confirmed COVID-19. Logistic regression defined the association of D-dimer levels, COVID-19 positivity, age, and gender with 30-day-mortality. 953 consecutive patients (median age 58, 43% women) presented with suspected COVID-19: 12 (7.4%) patients with confirmed SARS-CoV-2-infection died, compared with 28 (3.5%) patients without SARS-CoV-2-infection. Overall, most (56%) patients had elevated D-dimer levels (≥0.5mg/l). Age (OR 1.07, CI 1.05-1.10), D-dimer levels ≥0.5mg/l (OR 2.44, CI 0.98-7.39), and COVID-19 (OR 2.79, CI 1.28-5.80) were associated with 30-day-mortality. D-dimer levels are effective prognosticators in both patient groups.
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