Recurrent hemolytic uremic syndrome during oral contraception
Hauglustaine, D.; Van Damme, B.; Vanrenterghem, Y.; Michielsen, P.
Clinical Nephrology 15(3): 148-153
1981
ISSN/ISBN: 0301-0430 PMID: 6168423 Document Number: 181078
A case is reported of a 23-year-old multiparous normotensive woman who developed HUS (hemolytic uremic syndrome) on 2 occasions. Both episodes had been preceded by relatively short periods of estrogen-progestogen contraceptive usage. Neither episode was accompanied by arterial hypertension. This syndrome is characterized by acute renal failure associated with histological lesions of thrombotic microangiopathy. Laboratory findings, treatment, and kidney transplant in both of the episodes are described. The 1st instance occurred 5 months postpartum and 4 months after starting the OC (oral contraceptive) use. The 2nd instance occurred 10 months after starting OC usage. In the intervening 8 years, the patient had used a pure progestogen contraceptive without problems. A table presents findings from a review of the literature regarding an association between HUS and estrogen use.
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