Clinical Reliability of point-of-care tests to support community based acute ambulatory care
Verbakel, J.Y.; Richardson, C.; Elias, T.; Bowen, J.; Hassanzadeh, R.; Shine, B.; Smith, I.; Hayward, G.; Van den Bruel, A.; Pendlebury, S.T.; Lasserson, D.
Acute Medicine 19(1): 4-14
2020
ISSN/ISBN: 1747-4892 PMID: 32226951 Document Number: 18097
To ensure clinicians can rely on point-of-care testing results, we assessed agreement between point-of-care tests for creatinine, urea, sodium, potassium, calcium, Hb, INR, CRP and subsequent corresponding laboratory tests. Community-dwelling adults referred to a community-based acute ambulatory care unit. The Abbott i-STATTM (Hb, clinical chemistry, INR) and the AfinionTM Analyser (CRP) and corresponding laboratory analyses. Agreement (Bland-Altman) and bias (Passing-Bablok regression). Among 462 adults we found an absolute mean difference between point-of-care and central laboratory analyses of 6.4g/L (95%LOA -7.9 to +20.6) for haemoglobin, -0.5mmol/L (95%LOA -4.5 to +3.5) for sodium, 0.2mmol/L (95%LOA -0.6 to +0.9) for potassium, 0.0mmol/L (95%LOA -0.3 to +0.3) for calcium, 9.0 μmol/L (95%LOA -18.5 to +36.4) for creatinine, 0.0mmol/L (95%LOA -2.7 to +2.6) for urea, -0.2 (95%LOA -2.4 to +2.0) for INR, -5.0 mg/L (95%LOA -24.4 to +14.4) for CRP. There was acceptable agreement and bias for these analytes, except for haemoglobin and creatinine.
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