Pentazocine-induced fibrous myopathy and localized neuropathy
Sinsawaiwong, S.; Phanthumchinda, K.
Journal of the Medical Association of Thailand 81(9): 717-721
1998
ISSN/ISBN: 0125-2208 PMID: 9737132 Document Number: 1806
A 47 year-old woman who had a 4-year history of intramuscular pentazocine injections in the lower extremities, developed gradual stiffness and weakness of the lower extremities. The thigh and buttock muscles were "wooden-hard" on palpation. The skin was hard, shiny and hairless. Associated clinical and electrophysiological polyradiculopathy and multiple mononeuropathy of the lower extremities were observed. Imaging studies showed calcification and fibrosis of the involved muscles. Muscle biopsy revealed fibrous myopathy. Caution in long-term usage and early recognition of pentazocine toxicity as a neuromuscular complication are important in order to prevent irreversible drug-induced fibrous myopathy and localized neuropathy.
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