Response of Lichen Planopilaris to Pioglitazone Hydrochloride
Peterson, E.L..; Gutierrez, D.; Brinster, N.K..; Lo Sicco, K.I..; Shapiro, J.
Journal of Drugs in Dermatology Jdd 18(12): 1276-1279
2019
ISSN/ISBN: 1545-9616 PMID: 31860218 Document Number: 18002
Lichen planopilaris (LPP) is a cicatricial alopecia that often causes permanent hair loss. Pioglitazone, a peroxisome proliferator activated receptor-gamma (PPAR- γ) agonist, has demonstrated immunomodulatory properties that may offer an effective treatment modality. This retrospective analysis describes 23 patients with LPP treated with adjunctive pioglitazone. Most (18/25) demonstrated significant reduction in patient-reported symptoms and clinical signs of inflammation. No adverse effects were reported.
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