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Human cancers transplanted in nude mice retain the expression of their organ-specific neoantigens

Thomson, D.M.; Neville, A.M.; Phelan, K.; Scanzano, R.S.; Vandevoorde, J.P.

European Journal of Cancer and Clinical Oncology 17(11): 1191-1197

1981

ISSN/ISBN: 0277-5379
PMID: 7199466
Document Number: 179861
Human cancers transplanted to nude mice seem to retain most features of the original tumor. To determine if organ-specific neoantigens were still expressed after transplantation, 4 different human cancers were assayed in the tube LAI assay. The LAI phenomenon measures the change in adherence properties of leukocytes that have bound an antigen to which they are sensitized immunologically. Four of 4 transplanted human cancers-pancreas, lung, breast and colon-stimulated an LAI+ response with leukocytes from patients with cancers of the same organ. The antitumor response was not as vigorous against a pool of transplanted tumor extracts as against those prepared from liver metastases. Nonetheless, the results add to the mounting evidence that human cancers express neoantigens to which most humans bearing cancers respond immunologically.

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Murahashi, I.; Hosoya, Y.; Mukae, K.; Honda, M.; Takasaki, E. 1991: Efficacy of a drug sensitivity test using fosfomycin on human urogenital cancers transplanted subcutaneously in nude mice Gan to Kagaku Ryoho. Cancer and ChemoTherapy 18(1): 127-129
Giovanella, B.C.; Yim, S.O.; Morgan, A.C.; Stehlin, J.S.; Williams, L.J. 1973: Brief communication: metastases of human melanomas transplanted in "nude" mice Journal of the National Cancer Institute 50(4): 1051-1053
Andersson, A.; Eizirik, D.L.; Hellerström, C.; Johnson, R.C.; Pipeleers, D.G. 1994: Morphology of encapsulated human pancreatic islets transplanted into nude mice Transplantation Proceedings 26(2): 802-803
Fujimoto, S.; Shrestha, R.D.; Miyazaki, M.; Endoh, F.; Shimura, T.; Sugasawa, H.; Takahashi, O.; Kawata, S.; Ohta, M.; Kurihara, M. 1984: Experimental hyperthermo-chemotherapy for human gastric carcinoma transplanted in the nude mice Gan to Kagaku Ryoho. Cancer and ChemoTherapy 11(12 Part 2): 2724-2728
Yamada, T.; Tanase, M.; Watanabe, A.; Sawada, H.; Yamada, Y.; Shino, Y.; Yamashita, J.; Matsuda, M.; Nakano, H. 1997: Evaluation of combination chemotherapy with 5-FU and CDDP for human gastric carcinoma transplanted into nude mice Gan to Kagaku Ryoho. Cancer and ChemoTherapy 24(1): 43-47
Guo, W.; He, R.G.; Zhang, Z.Y. 1992: The antitumor effect of DNL/rIL-2 and Pingyangmycin on human tongue carcinoma(Tca 8113) transplanted to Nude Mice Shanghai Kou Qiang Yi Xue 1(1): 40-42
Tsuyuki, K. 1984: Experimental combination chemo-radiotherapy on human breast carcinoma (MX-1) transplanted into nude mice Nihon Geka Gakkai Zasshi 85(5): 421-432
Wang, J.; Huang, C.; Wei, X.-Y.; Zhan, Z.-L.; Sun, H.; Yang, Y.; Li, K. 2008: Biological effect of endostatin on transplanted human lung adenocarcinoma Calu-6 tumor in nude mice Zhonghua Zhong Liu Za Zhi 30(4): 266-269
Okazaki, M.; Kubota, T.; Hanatani, Y.; Maruyama, K.; Tsuyuki, K.; Nakada, M.; Asanuma, F.; Ishibiki, K.; Abe, O. 1982: Microvascular architecture of human tumors transplanted in nude mice--its relationship to sensitivity to antineoplastic agents Gan to Kagaku Ryoho. Cancer and ChemoTherapy 9(8): 1433-1441
Fujimoto, S.; Takahashi, M.; Kiuchi, S.; Kobayashi, K.; Mutou, T.; Masaoka, H.; Shimanskaya, R.B.; Ohkubo, H. 1994: Hyperthermia-induced antitumor activity in human gastric cancer cells serially transplanted into nude mice Anticancer Research 14(1a): 67-71
Takada, S.; Tsuda, M.; Fujinami, S.; Yamamura, M.; Mitomi, T.; Katsunuma, T. 1986: Incorporation of alpha-1-antichymotrypsin into carcinoma cell nuclei of human stomach adenocarcinoma transplanted into nude mice Cancer Research 46(7): 3688-3691
Zhang, S.Y.; Dai, Z.Q.; Shu, Y.H.; Zhang, J.L.; Lin, Z.Q.; Wu, S.F.; Liu, Y.F.; Xu, L.Z. 1987: Establishment of human lung adenocarcinoma model in nude mice and sensitivity of the transplanted tumor to antitumor drugs Zhongguo Yao Li Xue Bao 8(4): 366-369
Fujii, G.; Sekiguchi, M.; Samaru, Y.; Miyamoto, Y.; Koishi, T.; Suzuki, K.; Sudo, K. 1979: Effect of lymphoid cells sensitized in vitro on the growth of autochthonous human gastric cancer transplanted in "nude mice" Japanese Journal of Experimental Medicine 49(3): 219-222
McLemore, T.L.; Liu, M.C.; Blacker, P.C.; Gregg, M.; Alley, M.C.; Abbott, B.J.; Shoemaker, R.H.; Bohlman, M.E.; Litterst, C.C.; Hubbard, W.C. 1987: Novel intrapulmonary model for orthotopic propagation of human lung cancers in athymic nude mice Cancer Research 47(19): 5132-5140
Shirasaka, T.; Fujita, F.; Fujita, M.; Fukushima, M.; Taguchi, T.; Fujii, S. 1990: Antitumor activity and metabolism of BOF-A2, a new 5-fluorouracil derivative, with human cancers xenografted in nude mice Gan to Kagaku Ryoho. Cancer and ChemoTherapy 17(9): 1871-1876
Hinkelbein, W.; Wallbrecher, E.; Fiebig, H.H.; Wannenmacher, M. 1989: Fractionated irradiation under ambient conditions of human NSCLC transplanted into nude mice: effect of different fractionation schedules and of radiotherapy and vindesine Strahlentherapie und Onkologie: Organ der Deutschen Rontgengesellschaft . 165(7): 519-520
Graem, N. 1986: Epidermal changes following application of 7,12-dimethylbenz(a)anthracene and 12-O-tetradecanoylphorbol-13-acetate to human skin transplanted to nude mice studied with histological species markers Cancer Research 46(1): 278-284
Shen, M.; Feng, Y.; Zhou, X. 1999: Effect of liposome-C-erbB2 antisense oligodeoxynucleotides on the growth and the chemotherapeutic drug sensitivity of human ovarian cancer transplanted in the omentum of nude mice Zhonghua Fu Chan Ke Za Zhi 34(2): 110-112
Fukatsu, H.; Yamada, H.; Nonomura, H.; Miyagawa, Y.; Hatano, Y.; Waki, M.; Hiraiwa, S.; Muramatsu, T.; Yamada, Y.; Nishikawa, E. 1987: Study on heterotransplantation of human malignant urogenital tumors in nude mice: establishment of the tumor line in nude mice from human primary ureteral tumor and its characteristics Hinyokika Kiyo. Acta Urologica Japonica 33(12): 1943-1950
Revazova, E.S. 1981: Effect of chemo- and radiotherapy on the growth of human strains of respiratory and excretory organ tumors transplanted in athymic mice Biulleten' Eksperimental'noi Biologii i Meditsiny 92(11): 593-596