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RNA synthesis in rat brain during pharmacological modification of norepinephrine metabolism

Kraeva, V.S.; Baru, A.M.

Ukrainskii Biokhimicheskii Zhurnal 53(5): 60-63

1981

ISSN/ISBN: 0201-8470
PMID: 6170141
Document Number: 179851
Norepinephrine metabolism and nuclear RNA (nRNA) synthesis in the rat brain are found to be conjugated. Under the effect of preparations inducing a disturbance in the norepinephrine (sodium diethyldithiocarbamate and reserpine) its content in the brain tissue lowers and the nRNA synthesis intensity decreases. Accumulation on total resources of norepinephrine in the brain under the effect of ipraside or its synaptic form (melipramine, Lu-5) intensifies the nRNA synthesis.

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