T-cell growth factor-mediated proliferation of lymphocytes from a T-chronic lymphocytic leukaemia patient lacking mitogen and alloantigen responsiveness
De Vries, J.E.; Vyth, F.A.; Mendelsohn, J.
Clinical and Experimental Immunology 43(2): 302-310
1981
ISSN/ISBN: 0009-9104 PMID: 6456094 Document Number: 178843
Peripheral blood lymphocytes from a patient with chronic lymphocytic leukemia of T cell origin (T-CLL PBL), were found to lack PHA . In spite of the presence of Ia-like antigens on 36% of the T-CLL PBL, negligible stimulator capacity in MLC was observed. T-CLL PBL proliferation could be induced and maintained both by exogenous T cell growth factor (TCGF) containing PHA, and mitogen-free TCGF. Responder and stimulator capacity restoration in MLC was obtained in the presence of mitogen-free TCGF. Apparently, the lack of response to mitogens and alloantigens of the T-CLL PBL has to be attributed to the failure of these cells to produce TCGF upon activation.