Top Abstract Purchase Related
Home
>
Node
>
Subnode

Mechanism of the hypocoagulemic effect and the active principle of a phosphatidylserine-containing anticoagulant

Chabanov, M.K.

Farmakologiia i Toksikologiia 44(4): 425-428

1981

ISSN/ISBN: 0014-8318
PMID: 7286200
Document Number: 178539
Experiments on animals in vitro showed that phosphatidylserine-containing anticoagulant (PhCA) inhibited factors X and VIII, restricted factor V activity and, to a less degree, that of factor VII, decreased the activity of fibrin-stabilizing factor, the degree of clot retraction and its tolerance to fibrinolysin. The activity of factor IX remained virtually unchanged under the influence of PhCA, whereas the contact phase was speeded up by 14%. Anticoagulant activity of PhCA was accounted for by the phosphatidyl molecule residue - glycerylphosphorylserine.

Document emailed within 1 workday
Secure & encrypted payments

Byshevskiĭ, A.S.; Sokolovskiĭ, S.R. 1982: Potentiation of the anticoagulant effects of a phosphatidylserine-containing anticoagulant and heparin Voprosy Meditsinskoi Khimii 28(2): 30-34
Das, N.; Chandran, P.; Chakraborty, S. 2011: Potent spermicidal effect of oleanolic acid 3-beta-D-glucuronide, an active principle isolated from the plant Sesbania sesban Merrill Contraception 83(2): 167-175
Barbanti, M.; Calanni, F.; Milani, M.R.; Marchi, E.; Semeraro, N.; Colucci, M. 1993: Therapeutic effect of a low molecular weight dermatan sulphate (Desmin 370) in rat venous thrombosis--evidence for an anticoagulant-independent mechanism Thrombosis and Haemostasis 69(2): 147-151
Fadok, V.A.; Laszlo, D.J.; Noble, P.W.; Weinstein, L.; Riches, D.W.; Henson, P.M. 1993: Particle digestibility is required for induction of the phosphatidylserine recognition mechanism used by murine macrophages to phagocytose apoptotic cells Journal of Immunology 151(8): 4274-4285
Nakano, M. 1974: The adjuvant effect of bacterial endotoxin: its active component and action mechanism Nihon Rinsho. Japanese Journal of Clinical Medicine 32(8): 2715-2722
Yang, Y.-M.; Wang, X.-X.; Wang, S.-J.; Wang, H.-Q.; Chen, J.-Z. 2008: Suppressive effect in vitro of resveratrol on ADP induced human platelet aggregation and its active mechanism Yao Xue Xue Bao 43(4): 356-360
Byshevskiĭ, A.S.; Mukhacheva, I.A.; Lapuseva, T.M. 1978: Effect of phosphatidylserine in hemocoagulating action of factors V, VIi and autoprothrombin C Biokhimiia 43(1): 78-82
Viganò, G.; Zoja, C.; Corna, D.; Rossini, M.; Pusineri, F.; Garattini, S.; Remuzzi, G. 1990: 17 beta-estradiol is the most active component of the conjugated estrogen mixture active on uremic bleeding by a receptor mechanism Journal of Pharmacology and Experimental Therapeutics 252(1): 344-348
Barth, A.; Michel, H.J.; Mattern, A. 1976: A new approach to the analysis of enzyme-active principle interactions Die Pharmazie 31(2): 100-101
Skliar, M.I.; Boland, R.L. 1979: Multiple molecular forms of the active principle of Solanum malacox Medicina 39(1): 38-42
Fessi, H.; Puisieux, F.; Marty, J.P.; Carstensen, J.T. 1980: Validity of Higuchi's Law in the case of tablets with a high concentration of active principle Pharmaceutica Acta Helvetiae 55(10): 261-269
Werling, H. 1986: Principle of active social adjustment--the foundation of effective geriatric health Zeitschrift für die Gesamte Innere Medizin und ihre Grenzgebiete 41(5): 141-144
Rozkin, M.I.; Levina, M.N.; Kameneva, N.S.; Usov, A.I.; Efimov, V.S. 1989: Study of the mechanism of the anticoagulant action of fucoidans Farmakologiia i Toksikologiia 52(3): 48-51
Das, B.; Kundu, J.; Bachar, S.Chandra.; Uddin, M.Aftab.; Kundu, J.Kumar. 2007: Antitumor and antibacterial activity of ethylacetate extract of Ludwigia hyssopifolia linn and its active principle piperine Pakistan Journal of Pharmaceutical Sciences 20(2): 128-131
Shaparenko, P.F.; Krisiuk, A.P.; Kisil', I.I.; Goncharuk, V.P. 1996: The principle of the spiral-like structure of skeletal muscles--the basis for motor optimal performance of the active lower extremity Morfologiia 109(1): 71-75
Bordia, A.; Verma, S.K.; Khabia, B.L.; Vyas, A.; Rathore, A.S.; Bhu, N.; Bedi, H.K. 1977: The effective of active principle of garlic and onion on blood lipids and experimental atherosclerosis in rabbits and their comparison with clofibrate Journal of the Association of Physicians of India 25(8): 509-516
Lindhout, T.; Blezer, R.; Hemker, H.C. 1990: The anticoagulant mechanism of action of recombinant hirudin (CGP 39393) in plasma Thrombosis and Haemostasis 64(3): 464-468
Nivet, J.M. 1996: Statistic determination of release limits of a finished product active principle compared to drug specification at peremption and eventually at the end of its after reconstitution Annales Pharmaceutiques Francaises 54(3): 131-139
Hatch, R.C.; Jain, A.V.; Weiss, R.; Clark, J.D. 1982: Toxicologic study of carboxyatractyloside (active principle in cocklebur--Xanthium strumarium) in rats treated with enzyme inducers and inhibitors and glutathione precursor and depletor American Journal of Veterinary Research 43(1): 111-116
Günzel, P.; Siegmund, F.; Bhargava, A.S.; El Etreby, M.F.; Lang, R.; Poggel, H.A.; Schöbel, C.; Schuppler, J.; Staben, P. 1977: Experimental toxicity studies on fluocortin butylester in the forms of pure active principle, ointment, fatty ointment and cream in animals Arzneimittel-Forschung 27(11a): 2217-2221