DNA repair in xeroderma pigmentosum
Traupe, H.; Happle, R.; Kim, M.A.
Fortschritte der Medizin 99(7): 212-214
1981
ISSN/ISBN: 0015-8178 PMID: 7216102 Document Number: 178456
DNA-repair of two patients affected with xeroderma pigmentosum was evaluated in lymphocytes after UV-exposure by mitotic index, sister chromatid exchange (SCE) and nucleoid sedimentation. The first patient showed no increase in SCE-rate and a sedimentation profile typical of repair deficient cells. In the second patient an increase in SCE-rate and a considerable, but delayed DNA-repair activity in nucleoid sedimentation was found indicating 2 genetically different defects of DNA-repair. In the second patient a defect of postreplication repair is assumed.