Response to initial treatment of low and intermediate risk gestational trophoblastic disease with methotrexate and folinic acid
Tonanont, M.; Inthasorn, P.; Boriboonhirunsarn, D.; Wongthiraporn, W.; Suphanit, I.
Journal of the Medical Association of Thailand 88(10): 1349-1354
2005
ISSN/ISBN: 0125-2208 PMID: 16519378 Document Number: 17842
To evaluate the response and toxicity of methotrexate and folinic acid given as primary treatment of low and intermediate risk gestational trophoblastic disease (GTD). Medical records review was performed in patients who received methotrexate and folinic acid as a primary treatment of low and intermediate risk persistent GTD between January 1992 and December 2001. Response was defined as decline of beta human chorionic gonadotropin (hCG) to < or = 5 mlU/ml (remission) after methotrexate and folinic acid treatment. Response rate was estimated and factors associated with response were evaluated. Ninety four eligible patients were treated with intramuscular methotrexate and folinic acid. Complete remission was achieved in 64 cases (68%, 95% CI 58-78%). Mucositis (6.4%) and hepatotoxicity (6.4%) were the most common toxicity of methotrexate in the present study and none of these toxic effects was life threatening. Factors associated with response were initial serum hCG < or = 10,000 mlU/ml and stage I disease. Methotrexate with folinic acid is effective treatment for low and intermediate risk GTD with minimal severe toxicity.
Document emailed within 1 workday
