Efficient elimination of lipid-soluble toxic substances by silicone oil hemodialysis
Shibata, N.; Okamura, J.; Monden, M.; Fujimoto, T.; Uozumi, M.; Hashimoto, M.; Tyuma, I.; Wada, H.; Kosaki, G.
Medical Journal of Osaka University 32(1-2): 1-10
1981
ISSN/ISBN: 0030-6169 PMID: 7345356 Document Number: 178193
Some toxic metabolites which accumulate in blood during hepatic coma can be eliminated efficiently by an artificial liver support system, mainly by means of direct hemoperfusion or hemodialysis. Water-soluble substances can be eliminated effectively by conventional hemodialysis but lipid-soluble substances can not. The efficiency of a newly developed system called a silicone oil hemodialysis system in eliminating lipid-soluble substances was studied in dogs. The blood concentration of indole or glutethimide, which was chosen as a lipid-soluble substance to eliminate, was determined before, during and after hemodialysis. About 80% of these lipid-soluble substances was cleared by silicone oil hemodialysis. Silicone oil hemodialysis may be useful in the clearance of lipid-soluble substances which have high protein binding and low water solubility. The safety of this system was examined with satisfactory results.