Behavioral supersensitivity to methamphetamine following chronic treatment with (--) -sulpiride in the rat
Montanaro, N.; Dall'Olio, R.; Gandolfi, O.; Vaccheri, A.
Bollettino della Societa Italiana di Biologia Sperimentale 57(4): 401-406
1981
ISSN/ISBN: 0037-8771 PMID: 7195265 Document Number: 176911
Hyperactivity induced by methamphetamine (4 mg/kg i.p.) was actographically evaluated in rats chronically treated with sulpiride stereoisomers and haloperidol. The trial was repeated with half dose of the stimulant after 8 days of neuroleptic withdrawal. (--)-Sulpiride and haloperidol antagonized the response to the full dose of methamphetamine and induced behavioral supersensitivity to the challenging dose. (+)-Sulpiride strongly enhanced the effect of 4 mg/kg of methamphetamine, but no relevant changes in dopaminergic sensitivity followed.