The biodistribution and metabolic fate of inhaled 11C-octanal in the rat after acute exposure
Kutzman, R.S.; Meyer, G.J.; Wolf, A.P.; Akasaka, T.
Drug Metabolism and Disposition the Biological Fate of Chemicals 9(4): 331-333
1981
ISSN/ISBN: 0090-9556 PMID: 6114832 Document Number: 176447
Rats were nose exposed to an atmosphere containing 11.4 ppm of 11C-octanal for 2 min. Inhaled octanal was absorbed from the lungs in a biphasic manner and the greatest concentration of octanal occurred in most tissues at 5 min. Tissue activities calculated on the basis of the administered dose and on the radiolabel retained until the animal was killed indicated a redistribution of the radiolabel as metabolic products after 20 min. The labeled carbon was eliminated in a biphasic manner as 11CO2, which accounted for essentially all of the activity lost by the exposed rats.