Promotion of carcinomas by repeated abrasion in initiated skin of mice
Argyris, T.S.; Slaga, T.J.
Cancer Research 41(12 Part 1): 5193-5195
1981
ISSN/ISBN: 0008-5472 PMID: 7307015 Document Number: 175748
Repeated abrasion of the skin of Sencar mice initiated with 100 nmol of dimethylbenzanthracene resulted in the appearance of carcinomas in addition to papillomas. These results strongly support the argument that repeated epidermal regeneration is a sufficient stimulus for the promotion of both benign and malignant neoplasms in the skin of mice.
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