The effect of polymorphonuclear leukocyte (PMNL) factors on T suppressor cell function in in vitro studies in healthy persons and some autoimmune disorders
Czernicki, J.; Tchórzewski, H.; Lewicki, R.; Orzel, H.
Archivum Immunologiae et Therapiae Experimentalis 29(3): 355-360
1981
ISSN/ISBN: 0004-069X PMID: 6457583 Document Number: 175033
Lysosome proteins derived from peripheral blood granulocytes of patients with multiple sclerosis (MS), lupus erythematosus (LE), rheumatoid arthritis (RA) and recurrent uveitis cause the impairment of Con A-induced suppressor cell activity in two-step culture in vitro. This effect is independent of lysosome protease activity. Such a phenomenon, observed in vitro, may cause disturbances in suppressor cell function in the course of the above diseases.