Protective effect of Sambucus willamsii hance fruit oil on acute liver injury in mice
Lu, B.; Zhao, M.; Yang, X.; Liu, Q.; Liu, T.; Pan, M.; Lin, X.
Wei Sheng Yan Jiu 47(3): 437-464
2018
ISSN/ISBN: 1000-8020 PMID: 30082013 Document Number: 17488
To study the protective effect of Sambucus willamsii Hance fruit oil on acute liver injury in mice. Sixty male mice were randomly divided into six groups: normal control, model, positive control( salvianolic acid A, SAA) and Sambucus Willamsii Hance fruit oil groups( oil-H, oil-M and oil-L). The mice were daily administered Sambucus willamsii Hance fruit oil at the dosage of 2. 0, 4. 0 and 12. 0 g/kg for the groups of oil-L, oil-M, oil-H, respectively, while the same volume of 1% CMC was given to normal control groups and model ones for four weeks. After twenty-four hours from the last administration, the mice( except the normal control group) were injected intraperitoneally with CCl_4( 20 mg/kg). All the mice were sacrificed sixteen hours later, and serum and liver of the mice were collected for biochemical index determination. The result showed that compared with the model group, the serum aspartate aminotransferase( AST) and alanine aminotransferase( ALT) levels in the Sambucus willamsii Hance fruit oil groups decreased significantly( P < 0. 05). MDA levels reduced( P < 0. 05), while SOD and GSH-Px level increased( P < 0. 05). Moreover, the improvement effect of the above indexes was not different from that of the positive control group( P > 0. 05). Therefore, moderate intake of Sambucus willamsii Hance fruit oil exhibits a significantly protective effect on acute liver injury in mice.
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