Self-renewal capacity of leukemic blast progenitor cells
Buick, R.N.; Chang, L.J.; Messner, H.A.; Curtis, J.E.; McCulloch, E.A.
Cancer Research 41(11 Part 2): 4849-4852
1981
ISSN/ISBN: 0008-5472 PMID: 6945908 Document Number: 174814
A review is presented of experimental information pertaining to the characteristics of a procedure designed to quantitate the capacity for self-renewal in clonogenic cells of human acute myeloblastic leukemia. In a series of 44 previously untreated patients, a significant correlation (p less than 0.01) was seen between low capacity for self-renewal and successful remission induction. Three cytotoxic drugs (Adriamycin, 1-beta-D-arabinofuranosylcytosine, and N-[4-(19-acridinylamino)-3-methoxyphenyl]-methanesulfonamide) were tested for preferential effect against self-renewal events. Surviving clonogenic cells to these agents had, respectively, unchanged, lower, and higher capacity for self-renewal. The implications of such drug properties are discussed.