Intravenous Tranexamic Acid before and after Tourniquet use can Reduce Blood Loss and Blood Transfusion after Total Knee Arthroplasty

Numkanisorn, S.; Chareancholvanich, K.; Pornrattanamaneewong, C.

Journal of the Medical Association of Thailand 99(11): 1220-1225

2016


ISSN/ISBN: 0125-2208
PMID: 29901938
Document Number: 17384
Tranexamic acid (TXA) is commonly used to reduce blood loss and blood transfusion in total knee arthroplasty (TKA). However, studies regarding the efficacy of intravenous TXA given during the intra-operative period are limited. To study the efficacy of intra-operative TXA regimen on reducing blood loss and blood transfusion in TKA. In this retrospective comparative study, 60 patients were divided into two groups. Patients in Group 1 were given 10 mg/kg intravenous TXA 10 minutes before inflation of the tourniquet and again immediately after deflation of the tourniquet. Patients in Group 2 did not receive TXA. Blood loss, blood transfusion, and complications were compared between the two groups. Study findings revealed that intra-operative TXA regimen could significantly reduce drained blood (660±117.8 ml vs. 1,141.7±157.9 ml, p<0.001), decreasing hemoglobin at 12 hours (1.8±0.3 g/dL vs. 2.5±0.5 g/dL, p<0.001) and blood transfusion (26.7% vs. 80.0%, p<0.001) with no increase in procedure-associated complications. Intra-operative TXA regimen has the efficacy on reducing blood loss and blood transfusion requirement in TKA without potential risk of complications.

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Intravenous Tranexamic Acid before and after Tourniquet use can Reduce Blood Loss and Blood Transfusion after Total Knee Arthroplasty