Incidence of and Risk Factors for Acute Respiratory Distress Syndrome in Patients Admitted to Surgical Intensive Care Units: The Multicenter Thai University- Based Surgical Intensive Care Unit (THAI-SICU) Study
Chaiwat, O.; Chittawatanarat, K.; Piriyapathsom, A.; Pisitsak, C.; Thawitsri, T.; Chatmongkolchart, S.; Kongsayreepong, S.
Journal of the Medical Association of Thailand 99 Suppl. 6: S118-S127
2016
ISSN/ISBN: 0125-2208 PMID: 29906368 Document Number: 17366
The incidence and outcomes of acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) are unclear. We evaluated the cumulative incidence of, risk factors for, and outcomes of ALI/ARDS in surgical ICUs (SICUs). The multicenter Thai University-based Surgical Intensive Care Unit (THAI-SICU) study was a In total, 4,652 patients were analyzed. ALI/ARDS new developed in 114 patients (2.5%). Patients with ALI/ARDS had higher APACHE II (20.0 vs. 11.4, respectively; p<0.001) and SOFA scores (7.3 vs. 3.1, respectively; p<0.001) and a higher incidence of past or current smoking (48% vs. 36%, respectively; p<0.001) than the non-ARDS patients. The 28-day mortality rate was significantly higher in patients with than without ALI/ARDS (50% vs. 12%; p<0.001). Higher APACHE II and SOFA scores and higher rates of current or past smoking were independent predictors of ALI/ARDS. The incidence of ALI/ARDS in the THAI-SICU study was low, but the mortality rate was high. Higher severity scores and smoking were associated with ALI/ARDS.