Immunohistochemistry of Cytokeratin 7, Cytokeratin 20 and Thyroid Transcription Factor-1 in Metastatic Carcinoma of Cervical Lymph Node Biopsy for Identification of Pulmonary Origin in Rajavithi Hospital
Kuakpaetoon, T.
Journal of the Medical Association of Thailand 100(Suppl 1): S172-S176
2017
ISSN/ISBN: 0125-2208 PMID: 29927559 Document Number: 17358
One of the most powerful tools used in "the team approach in modern medicine" is immunohistochemistry, a To study the expression of CK7, CK20 and TTF-1 in metastatic carcinoma in neck node biopsy found in the Rajavithi Hospital database, and to assess their effectiveness in identifying pulmonary origin. The Rajavithi Hospital database was searched for all cases of lymph node biopsy in the neck and Average age of the subjects, of whom 56.9% were male, was 61.35±12.9 years. Lung (51.2%), breast (7.3%) and gastrointestinal tract (6.5%) were the three most common organ site origins, and the most common cell type was adenocarcinoma. Expressions are shown in terms of sensitivity (98.4%), specificity (95.0%), positive predictive value (95.4%), negative predictive value (98.3%) and others. The most reliable antibody for identification of pulmonary origin was TTF-1. The immunohistochemistry panel of CK7, CK20 and TTF-1 in the Rajavithi Hospital database is useful as a guide in locating the origin of clinically unknown primary cases of metastatic cervical lymph nodes.