Ketotifen in the oral prophylaxis of bronchial asthma: a review
Craps, L.
Pharmatherapeutica 3(1): 18-35
1981
ISSN/ISBN: 0308-051X PMID: 6119703 Document Number: 173453
The experimental data providing the rationale for the use of ketotifen as a prophylactic drug in asthma (inhibition of release of the mediators of anaphylaxis, particularly SRS-A , prevention of the bronchospasm induced by SRS-A in vivo, Ca antagonist effect) are briefly discussed. Results of experimental and therapeutic trials carried out over 6 yr in a number of countries in several thousand patients are reviewed. Some important features of oral asthma prophylaxis with ketotifen are underlined: the effect of ketotifen on the characteristic bronchial hyperreactivity of asthma; the types of asthma which respond best to ketotifen treatment; the effect of ketotifen in reducing the concomitant use of corticosteroids and bronchodilators; a comparison of ketotifen with specific antihistamines, theophylline derivatives and sodium cromoglycate; and the side effects and long-term safety of ketotifen.