Efficacy of Donepezil in the Treatment of Obstructive Sleep Apnea: a Placebo-Controlled Trial
Hunchaisri, N.; Chalermsuwiwattanakan, W.
Journal of the Medical Association of Thailand 99(Suppl 8): S31-S35
2016
ISSN/ISBN: 0125-2208 PMID: 29901379 Document Number: 17305
The treatments of obstructive sleep apnea (OSA) consist of surgical such as uvulopalatopharyngoplasty and To evaluate the efficacy of donepezil in the treatment of obstructive sleep apnea (OSA). A prospective, randomized study was conducted at HRH Princess Maha Chakri Sirindhorn Medical At the end of the study, 41 patients were collected of which 21 patients were in study group and 20 patients were in control group. Before treatment, there were no significant difference in age (p = 0.53), body mass index (p = 0.80), sex (p = 0.44), minimum SpO2 (p = 0.36), Epworth sleepiness Scale scores (p = 0.86), and AHI (p = 0.06) between two groups. After treatment, no statistically significant difference in the value of AHI, minimum SpO2 and Epworth Sleepiness Scale scores were identified both in the same group and between two groups (p>0.05). Treatment OSA patients with donepezil did not show better results than placebo.