Effects of resination on actions of anorexigenic agents
Zabik, J.E.; Webb, R.W.; Maickel, R.P.
Methods and Findings in Experimental and Clinical Pharmacology 3(3): 161-172
1981
ISSN/ISBN: 0379-0355 PMID: 7253772 Document Number: 172656
The salt and resinated forms of three anorexigenic agents, d-amphetamine, d,1-amphetamine, and phentermine were examined in rats using two test systems. Appetite depression was determined using a deprivation-induced food consumption test and central stimulatory activity was measured by a two-lever continuous avoidance responding task. Dose-response and time-response studies indicated that the resinated forms of all three compounds had a delayed onset of action as anorexigenic agents and a reduced degree of central stimulatory activity as compared to the salt forms.