Submammary Granular Parakeratosis Treated with Mastopexy
Nelson, G.; Lien, M.H.; Messina, J.L.; Ranjit, S.; Fenske, N.A.
Journal of Drugs in Dermatology Jdd 16(8): 810-812
2017
ISSN/ISBN: 1545-9616 PMID: 28809996 Document Number: 17247
Granular parakeratosis, originally named axillary granular parakeratosis, is an uncommon disease with an unclear etiology. It is thought to result from defective processing of profillagrin to fillagrin, causing retention of keratohyaline granules in the epidermis. A myriad of causative factors has been proposed, including friction, moisture, heat, and contact irritants such as deodorants. We present a case in the inframammary area that resolved with mastopexy, further supporting the role of friction, moisture, and heat. Furthermore, we present electron microscopic evidence demonstrating non-degraded keratohyaline granules upon epidermal maturation. This entity, we believe, is reactive and represents a protective response of the body to moisture and heat.
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