Cefotaxime in the treatment of severe infections due to multiresistant Gram-negative bacilli
Clumeck, N.; Van Laethem, Y.; Vanhoof, R.; Jaspar, N.; George, G.; Rapin, M.; Butzler, J.P.
La Nouvelle Presse Medicale 10(8): 622-624
1981
ISSN/ISBN: 0301-1518 PMID: 6259606 Document Number: 172342
Cefotaxime was used to treat 33 patients with serious Gram-negative bacillary infections. The dosage varied between 1.5 g and 4 g/day in patients without renal failure. Eighteen patients had urinary tract infections, 6 had pulmonary infections and 10 had miscellaneous infections. Sixteen patients were also bacteremic. Twenty-five infections were due to pathogens resistant to ampicillin, cephalothin, gentamicin and/or tobramycin, in vitro. Fifteen infections had failed to resolve during ampicillin, cefazolin, gentamicin or tobramycin therapy. Thirty-two patients responded favourably (cure or improvement). Four patients developed superinfection with cefotaxime-resistant bacteria. One patient developed mild reversible renal insufficiency. Cefotaxime is a very active cephalosporin with potential use in serious multi-resistant enterobacteria infections.