Possible ways of modeling latent influenzae infection in mice
Zuev, V.A.; Pavlenko, R.G.; Mirchink, E.P.; Kharitonova, A.M.; Beliaev, D.L.
Voprosy Virusologii 1981(3): 280-285
1981
ISSN/ISBN: 0507-4088 PMID: 7293159 Document Number: 172260
A latent influenza infection was produced experimentally by 3 methods: after experiencing the disease, after immunization with a live virus and as a result of vertical transmission of the virus persisting in females. In latent influenza infection forming after the disease the duration of virus persistence was 112 days postinfection. The persisting virus from the animals receiving a single immunization was isolated only up to 35 days postinoculation. The persisting infectious virus was found in the lungs in low titers. A latent influenza infection in mice born to virus carrier mothers was characterized by virus persistence in the blood and viscera. Features of influenza virus persistence and conditions of its formation in mammals are discussed.