Typical nature of th primary short-term bacteremia in experimental shigellosis
Bondarenko, V.M.; Pavlovich, S.I.
Zhurnal Mikrobiologii Epidemiologii i Immunobiologii 11: 18-21
1981
ISSN/ISBN: 0372-9311 PMID: 7324649 Document Number: 171598
The comparative histological study of morphological changes in the intestine of monkeys and in the isolated loop of the small intestine of rabbits and mice infected with dysentery bacteria showed the possibility of using the intragastric infection of white mice as a model allowing one to study some aspects of the pathogenesis of dysentery. In experiments on monkeys, rabbits and white mice infected with Sh. dysenteriae, Sh, flexneri, Sh, newcastle, Sh, boydii and Sh. sonnei the presence of shortterm bacteremia was revealed in all cases of infection. The systematic detection of the causative agents of dysentery in the blood was possible only during the first 6 hours of the experimental infectious process. The release of shigellae from the intestine into the blood flow and their dissemination was confirmed by the detection of shigellae in the blood and internal organs of the animals in the bacteriological study and by the fluorescent antibody method.