Evaluation of cephradine-chemoprophylaxis in Cesarean section
Papaloucas, A.; Kotoulas, I.G.; Paradelis, A.G.
Methods and Findings in Experimental and Clinical Pharmacology 3(1): 29-32
1981
ISSN/ISBN: 0379-0355 PMID: 7230973 Document Number: 171472
The clinical efficacy of the prophylactic use of cephradine was evaluated prospectively in 118 women who underwent cesarean section. The patients of the cephradine group had a significantly lower (p less than 0.01) postoperative morbidity rate (17.79%) as compared with the control group (51.06%). The mean hospitalization time was also significantly shorter (p less than 0.01) in the cephradine group (7.2 +/- 0.13) than in the control group (10.9 +/- 0.23). Cephradine was proved to be an effective antimicrobial agent for chemoprophylaxis, due to its wide antimicrobial spectrum, beta-lactamase resistance, low percentage protein binding, large volume of distribution and non metabolic degradation.