Experimental autoimmune glomerulonephritis replicated in several generations of immunized animals
Vikhert, A.M.; Bykovskaia, K.N.
Arkhiv Patologii 43(11): 19-25
1981
ISSN/ISBN: 0004-1955 PMID: 7316828 Document Number: 171391
Experimental autoimmune glomerulonephritis was reproduced in 10 generations of animals by parenteral inoculation on two occasions of 0.3 ml of a mixture (1 :1) of AF stimulator and 20% renal cortical layer homogenate. The animals were immunized with minimal doses which routinely did not cause renal pathology, however, in sequential regular immunization from generation to generation the renal pathology increased. The forth-fifth generation exhibited clinical signs typical of glomerulonephritis. Morphological examinations of the kidneys revealed mesangial-proliferative and membranous-proliferative glomerulonephritis.