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A quantitative assessment of duodenogastric reflux in the dog after meals and under pharmacological stimulation

Sonnenberg, A.; Müller-Lissner, S.A.; Schattenmann, G.; Lepsien, G.; Hollinger, A.; Siewert, J.R.; Blum, A.L.

Scandinavian Journal of Gastroenterology. Suppl 67: 103-105

1981

ISSN/ISBN: 0085-5928
PMID: 6941382
Document Number: 171108
Duodenogastric reflux was measured in the dog by a double marker technique which does not interfere with the gastroduodenal junction. Duodenogastric reflux occurred both with a lipid and a protein meal. The gastric accumulation of duodenal contents was higher with fat than with protein because fat slowed gastric emptying. It was even higher with atropine because in addition to slowing gastric emptying atropine also increased the reflux rate. The effect of atropine was offset by a histamine H1 agonist.

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