Effectiveness and Safety of Radioactive Iodine Therapy in Childhood Graves' Disease in Khon Kaen, Thailand
Getsuwan, S.; Wiromrat, P.; Panamonta, O.; Panamonta, M.; Paireepinas, S.
Journal of the Medical Association of Thailand 99(Suppl 5): S112-S119
2016
ISSN/ISBN: 0125-2208 PMID: 29905996 Document Number: 17100
Graves' disease (GD) is the most common cause of hyperthyroidism in children and adolescents. Treatments To evaluate the effectiveness and safety of RAI therapy in childhood GD. A retrospective study was performed in 46 GD patients, aged at onset <15 years, who had undergone The cure rate was 95.6%. All participating patients had goiter reduction (p = 0.005). Hypothyroidism was induced in 33 (71.7%) and 11 (23.9%) patients after the first and second RAI therapy. The total RAI dosage was significantly higher in the patients with failure response (p = 0.001). The average time to induce hypothyroidism after the first RAI therapy was 127.5 (IQR: 94.5-223.0) days. All of the patients had improvement of ophthalmopathy and none had thyroid carcinoma during the follow-up period of 42.5 (IQR: 17-52) months. Radioactive iodine therapy is effective and safe in the treatment of children and adolescents with Graves'