Top Abstract Purchase Related
Home
>
Node
>
Subnode

Use of human mammary epithelial antigens (HME-Ags) in breast cancer diagnosis

Ceriani, R.L.; Orthendahl, D.; Sasaki, M.; Kaufman, L.; Miller, S.; Wara, W.M.; Peterson, J.A.

Cancer Detection and Prevention 4(1-4): 603-609

1981

ISSN/ISBN: 0361-090X
PMID: 7349827
Document Number: 170791
The use of human mammary epithelial antigens (HME-Ags) was explored in detection of human breast cancers. Specific antibodies were made against HME-Ags, which are normal differentiation antigens of human breast epithelium, and were used in a solid phase radioimmunoassay. Circulating HME-Ags were detected in sera of breast cancer patients with high-tumor load. These antibodies, after radioiodination, were also successfully used to localize human breast tumors grafted in athymic nude mice by whole body radioimaging devices. These results suggest that HME-Ags can be applied to breast cancer diagnosis with higher specificity than those already reported.

Document emailed within 1 workday
Secure & encrypted payments

Artamonova, E.V.; Tupitsyn, N.N.; Kadagidze, Z.G.; Letiagin, V.P.; Ermilova, V.D.; Ognerubov, N.A.; Panichenko, A.V.; Riazantseva, S.N. 2002: The role of epithelial antigens in diagnosis and staging of breast cancer Arkhiv Patologii 64(6): 13-15
Liang, P.; Averboukh, L.; Keyomarsi, K.; Sager, R.; Pardee, A.B. 1992: Differential display and cloning of messenger RNAs from human breast cancer versus mammary epithelial cells Cancer Research 52(24): 6966-6968
Remennik, L.V.; Litvinov, S.V.; Kriukova, I.N.; Chuev, I.V. 1985: Expression of antigens immunologically related to the antigens of the mouse mammary tumor virus in the tissue of human breast tumors Biulleten' Eksperimental'noi Biologii i Meditsiny 99(6): 734-736
Croce, M.V.; Colussi, A.G.; Price, M.R.; Segal-Eiras, A. 1997: Expression of tumour associated antigens in normal, benign and malignant human mammary epithelial tissue: a comparative immunohistochemical study Anticancer Research 17(6d): 4287-4292
Falany, J.L.; Falany, C.N. 1996: Expression of cytosolic sulfotransferases in normal mammary epithelial cells and breast cancer cell lines Cancer Research 56(7): 1551-1555
Kriukova, I.N.; Lushnikova, A.A.; Makhov, P.B.; Malivanova, T.F.; Laktionov, K.P. 2001: An antigen related to the mouse mammary cancer virus env gene product, detected in human lymphocytes, is associated with human breast cancer Molekuliarnaia Genetika Mikrobiologiia i Virusologiia 2: 37-41
Malivanova, T.F.; Litvinov, S.V.; Plevaya, E.B.; Kryukova, I.N. 1988: Detection in the blood serum of breast cancer patients of circulating immune complexes containing antigens showing common epitopes with structural proteins of mouse mammary tumour virus (MMTV) Acta Virologica 32(2): 129-137
Biswal, B.M.; Kumar, R.; Julka, P.K.; Sharma, U.; Vaidya, M.C. 1998: Human leucocytic antigens (HLA) in breast cancer Indian Journal of Medical Sciences 52(5): 177-183
Brennan, M.J. 1976: Murine and rat mammary tumors as models for the immunological study of human breast cancer Cancer Research 36(2 Part 2): 728-733
Wang, Y.; Holland, J.F.; Bleiweiss, I.J.; Melana, S.; Liu, X.; Pelisson, I.; Cantarella, A.; Stellrecht, K.; Mani, S.; Pogo, B.G. 1995: Detection of mammary tumor virus env gene-like sequences in human breast cancer Cancer Research 55(22): 5173-5179
Shay, J.W.; Wright, W.E.; Brasiskyte, D.; Van der Haegen, B.A. 1993: E6 of human papillomavirus type 16 can overcome the M1 stage of immortalization in human mammary epithelial cells but not in human fibroblasts Oncogene 8(6): 1407-1413
Longman, S.M.; Buehring, G.C. 1987: Oral contraceptives and breast cancer. in vitro effect of contraceptive steroids on human mammary cell growth Cancer 59(2): 281-287
Wagner, C.R.; Ballato, G.; Akanni, A.O.; McIntee, E.J.; Larson, R.S.; Chang, S.; Abul-Hajj, Y.J. 1997: Potent growth inhibitory activity of zidovudine on cultured human breast cancer cells and rat mammary tumors Cancer Research 57(12): 2341-2345
Pierce, J.H.; Arnstein, P.; DiMarco, E.; Artrip, J.; Kraus, M.H.; Lonardo, F.; Di Fiore, P.P.; Aaronson, S.A. 1991: Oncogenic potential of erbB-2 in human mammary epithelial cells Oncogene 6(7): 1189-1194
Newman, R.A.; Klein, P.J.; Rudland, P.S. 1979: Binding of peanut lectin to breast epithelium, human carcinomas, and a cultured rat mammary stem cell: use of the lectin as a marker of mammary differentiation Journal of the National Cancer Institute 63(6): 1339-1346
Mitropoulou, T.N.; Tzanakakis, G.N.; Nikitovic, D.; Tsatsakis, A.; Karamanos, N.K. 2002: In vitro effects of genistein on the synthesis and distribution of glycosaminoglycans/proteoglycans by estrogen receptor-positive and -negative human breast cancer epithelial cells Anticancer Research 22(5): 2841-2846
Taylor-Papadimitriou, J.; Burchell, J.; Hurst, J. 1981: Production of fibronectin by normal and malignant human mammary epithelial cells Cancer Research 41(6): 2491-2500
Gollahon, L.S.; Shay, J.W. 1996: Immortalization of human mammary epithelial cells transfected with mutant p53 (273his) Oncogene 12(4): 715-725
Koda, M.; Kanczuga-Koda, L.; Reszec, J.; Sulkowska, M.; Famulski, W.; Baltaziak, M.; Kisielewski, W.; Sulkowski, S. 2004: Expression of the apoptotic markers in normal breast epithelium, benign mammary dysplasia and in breast cancer Folia Morphologica 63(3): 337-341
Yamashita, J.; Ogawa, M.; Beppu, T. 1993: Immunoreactive hepatocyte growth factor is present in tissue extracts from human breast cancer but not in conditioned medium of human breast cancer cell lines Research Communications in Chemical Pathology and Pharmacology 82(2): 249-252