Comparison of o-octopamine and related phenylethanolamines as substrates for norepinephrine N-methyltransferase
Fuller, R.W.; Hemrick-Luecke, S.K.; Midgley, J.M.
Research Communications in Chemical Pathology and Pharmacology 33(2): 207-213
1981
ISSN/ISBN: 0034-5164 PMID: 6795705 Document Number: 170530
o-Octopamine was a substrate for rabbit adrenal norepinephrine N-methyltransferase with lower affinity than the position isomers m-octopamine and p-octopamine. The order of substrate affinity for monochloro or monohydroxy phenylethanolamines was para greater than meta greater than ortho. With phenylethanolamine and ring-hydroxylated phenylethanolamines, primary amines were better substrates than were N-methyl secondary amines. N-Methylation might be a metabolic pathway for o-octopamine, reported to occur in mammalian tissues.