Regression of cardiac oxygen consumption on ventricular pressure-volume area in dog
Suga, H.; Hayashi, T.; Shirahata, M.; Suehiro, S.; Hisano, R.
American Journal of Physiology 240(3): H320-H325
1981
ISSN/ISBN: 0002-9513 PMID: 7212076 Document Number: 170311
Left vent4icular systolic pressure-volume area (PVA) was reported to be a reliable predictor of cardiac O2 consumption rate/beat (VO2) in a given heart with a stable inotropic background. PVA is the specific area in the pressure-volume (PV) diagram, consisting of the area (EW) within the PV loop and the area (PE) bound by the end-systolic and end-diastolic PV lines and the relaxation segment of the PV loop. EW and PE correspond to the external mechanical work and the end-systolic elastic potential energy in the ventricular wall, respectively. The optimal combinationof EW and PE for the best prediction of VO2, using the linear multiple regression analysis was determined. From EW, PE and VO2, data of many isovolumic and ejecting contractions, the optimal coefficients of EW and PE were 1.67 .+-. 0.43 (SD; 7 hearts) and 1.74 .+-. 0.49 (10-5 ml O2/mmHg.cntdot.ml), virtually identical to each other, corroborating that PVA, i.e., a simple sum of EW and PE, can reliably predict VO2 of a given heart in a stable contractile state.