Pathogenetic factors for onset of neovascularization in diabetic retinopathy
Niki, T.; Muraoka, K.; Kitagawa, M.; Hasunuma, T.; Tsuji, K.
Nippon Ganka Gakkai Zasshi 85(7): 668-683
1981
ISSN/ISBN: 0029-0203 PMID: 6171149 Document Number: 170260
An investigation was performed in order to determine which factors are responsible for the onset of retinal neovascularization in diabetic retinopathy. Eighty-eight eyes (72 cases), which developed neovascularization during the course of observation, were analyzed by means of wide-angle, panoramic fluorescein angiography taken before and after appearance of neovascularization. Each angiogram was subdivided into small blocks and each block was then numerically graded as to the degree of vasodilatation and capillary nonperfusion. The 88 eyes could be divided into 2 distinct groups based on characteristics of vasodilatation. In 37 eyes (29 cases) there was a generalized and intense vasodilatation during the initial stage which later became less intense. In the 2nd group of 51 eyes (44 cases), a mild vasodilatation persisted throughout the course of observation. In the 1st group, retinal neovascularization developed just when the vasodilatation became less intense. Neovascularization from the optic disc started to develop while the vasodilatation was persistent or became more intense. Rubeosis of the iris or the anterior chamber angle became manifest while a marked vasodilatation persisted in 4 eyes. Retinal neovascularization developed randomly in the 2nd group. In all cases there was a marked capillary nonperfusion area particularly in the midperipheral retina. Apparently retinal neovascularization does not normally develop while vasodilatation and capillary nonperfusion are in their progressive stage, but develops when vasodilatation becomes less intense. Neovascularizations from the optic disc and rubeosis iridis develop while vasodilatation and capillary nonperfusion are in their active and progressive stage.