Effect of sulphinpyrazone and aspirin on platelet adhesion to subendothelium following oral administration to rabbits
Davies, J.A.; Menys, V.C.
Thrombosis Research 21(4-5): 329-337
1981
ISSN/ISBN: 0049-3848 PMID: 7268688 Document Number: 170065
Sulfinpyrazone 20 mg/kg, aspirin 15 mg/kg or placebo were given orally to rabbits for 5 days. Platelets and samples of aorta were then prepared from treated animals. Adhesion of radiolabeled platelets to everted aorta was measured in a perfusion device. By using different combinations of placebo or drug-treated material, effects of sulfinpyrazone or aspirin on platelets, vascular cells, or both in combination were studied separately. Residual PGI2-like activity of vascular samples was assessed by inhibition of ADP-induced aggregation. Sulfinpyrazone treatment of aorta enhanced adhesion of normal platelets, though PGI2-like activity was only minimally reduced. Exposure of both aorta and platelets to the drug reduced platelet adherence. Treatment with aspirin almost totally abolished PGI2-like activity. There was a statistically insignificant trend towards increased platelet adhesion to treated aorta, but exposure of both tissues to aspirin did not affect adhesion. Sulfinpyrazone and aspirin differ in their effects on platelet adhesion to vascular surfaces.