Antithyroid effect of a food or drug preservative: 4-hydroxybenzoic acid methyl ester
Rousset, B.
Experientia 37(2): 177-178
1981
ISSN/ISBN: 0014-4754 PMID: 6263671 Document Number: 169602
4-Hydroxybenzoic acid methyl ester (methylparaben) inhibits organification of iodide by isolated hog thyroid cells. The concentration which produces a 50% inhibition was .apprx. 2.0 .times. 10-4 M. A similar inhibition was observed in nonstimulated and thyrotropin- or dibutyryl cAMP-stimulated cells. Neither iodide uptake nor cAMP generation were altered by methylparaben.
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