Cryotherapy in cervical disease
Sedlis, A.; Castadot, M.J.; Glatt, B.
New York State Journal of Medicine 81(12): 1757-1760
1981
ISSN/ISBN: 0028-7628 PMID: 6949053 Document Number: 169426
Two hundred and twenty-one women with CIN-1 and CIN-2 (mild or moderate cervical intraepithelial dysplasia) proved on colposcopic biopsy and 317 women with benign cervical disease were treated by cryotherapy. Of these, 178 CIN patients were followed from 6-80 mo. and monitored for residual disease with Papanicolaou smears and colposcopic biopsies; 43 patients were lost to follow-up. In 18 patients (10.1 percent) residual CIN-1, CIN-2, or progression to CIN-3 (severe dysplasia) was diagnosed from 6-50 mo. after cryotherapy; in 7 of these patients (39%), the diagnosis was made 18 or more mo. after treatment. Twelve patients with persistent CIN-1 or CIN-2 received second cryotherapy after which progression occurred in 2 patients and persistent disease was found in 3. Six patients showed no residual CIN. CIN-1 or CIN-2 was diagnosed in 4 out of 181 women treated with cryotherapy for benign cervical disease. All patients treated with cryotherapy for cervical neoplasia must be closely monitored for long periods of time because the residual disease occurs in over 10% of cases and may not be recognized for many months or years.