A comparative clinical study of dioxonium and pancuronium as muscle relaxants in small children
Iisalo, E.U.; Kanto, J.H.
International Journal of Clinical Pharmacology Therapy and Toxicology 19(6): 260-265
1981
ISSN/ISBN: 0174-4879 PMID: 7030973 Document Number: 169177
Dioxonium (30, 40, and 60 microgram/kg i.v.), a new depolarizing agent, weas compared with pancuronium (0.05 and 0.1 mg/kg i.v.) as a muscle relaxant in combination anesthesia during general surgical operations in small children. Generally, the conditions during intubation, maintenance of anesthesia, and in the recovery room were comparable after both drugs. There were no differences in the cardiovascular responses either. However, a wider intra- and interindividual variation in the drug response was observed after dioxonium, especially after repeated administrations.