The role of circulating immune complexes in pregnancy
Kuramoto, M.
Nihon Sanka Fujinka Gakkai Zasshi 33(11): 1897-1904
1981
ISSN/ISBN: 0300-9165 PMID: 7320592 Document Number: 168632
The circulating immune complexes in pregnancy sera have been thought to act immunosuppressively to the maternal lymphoid system, and to be one of the causes of toxemia of pregnancy. Circulating immune complexes were detected in human pregnancy sera using the A were evaluated. There was a significant positive correlation (P < 0.01, P < 0.02, respectively). The correlation between immune complexes and clinical symptoms of toxemia of pregnancy in terms of the Gestosis Index was evaluated. There was no significant correlation at the time of sampling, but highly significant correlation was obtained at the time of admission for labor. The differences of Gestosis Indexes at the time of blood sampling and admission for labor were highly significant in the group of high immune complex titer. In cases of toxemia of pregnancy, the immune complex titer increased before the symptoms of toxemia of pregnancy appeared. Circulating immune complexes in pregnancy probably have the role of immunosuppression and act as one of the causes of toxemia of pregnancy.