Antibiotic activity in surgical incisions. The basis of prophylaxis in selected operations
Polk, H.C.; Trachtenberg, L.; Finn, M.P.
JAMA 244(12): 1353-1354
1980
ISSN/ISBN: 0098-7484 PMID: 7411809 Document Number: 167634
Perioperative antibiotic administration to produce systemic effects reduces the frequency of operative wound infection in selected procedures. Controlled clinical trials now indicate that cephalothin sodium may not be effective in this role, while cephaloridine and cefazolin sodium have been beneficial. Review of estimates of incisional antibiotic concentrations taken during prospective patient studies displays patterns compatible with these data. Each drug reaches acceptable incisional concentrations, which are relatively well maintained for cephaloridine and cefazolin; cephalothin disappears from human incisions so rapidly as to provide little wound protection in operations lasting > 1 h.