Effect of naftidrofuryl on high energy phosphates, glycogen, lactate and pyruvate in mouse hearts during asphyxia and post-asphyctic recovery
Estler, C.J.; Böcker, R.; Schinzel, W.
Archives Internationales de Pharmacodynamie et de Therapie 247(1): 39-42
1980
ISSN/ISBN: 0003-9780 PMID: 7447560 Document Number: 167626
The effect of naftidrofuryl (40 micrograms/g i.p.) on the ATP, phosphocreatine (PC), glycogen, lactate and pyruvate contents of the heart during respiratory arrest and postanoxic recovery was studied in mice. Naftidrofuryl increased he PC-content of the heart of normal mice. It did not prevent the metabolic changes brought about by 1 min anoxia but accelerated the post anoxic recovery of the depleted PC-content on account of delayed replenishment of the reduced glycogen stores. The changes in the ATP, lactate and pyruvate contents were not affected.