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Regulatory role of humoral factors released by macrophages in rat lymphocyte reactivity in vitro. II. Influence of humoral factors released by normal peritoneal macrophages on spontaneous lymphocyte stimulation

Brajczewska-Fischer, W.; Ryzewska, A.G.

Archivum Immunologiae et Therapiae Experimentalis 28(1): 27-32

1980

ISSN/ISBN: 0004-069X
PMID: 6968191
Document Number: 167413
Supernatants harvested from peritoneal macrophage cultures, derived from normal rats, exhibit in vitro the following 2 antagonistic activities: stimulating and suppressing spontaneous stimulation of syngeneic lymphocytes. Stimulation of DNA synthesis by macrophage supernatants occurs in lymph node lymphocytes, which show low values of spontaneous stimulation. Suppression of DNA synthesis by macrophage supernatants is revealed in thymocytes and cortisone-resistant thymocytes, which demonstrate high values of spontaneos stimulation.

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