The Clq receptor site on immunoglobulin G
Burton, D.R.; Boyd, J.; Brampton, A.D.; Easterbrook-Smith, S.B.; Emanuel, E.J.; Novotny, J.; Rademacher, T.W.; van Schravendijk, M.R.; Sternberg, M.J.; Dwek, R.A.
Nature 288(5789): 338-344
1980
ISSN/ISBN: 0028-0836 PMID: 6776418 Document Number: 167109
We propose that, the binding site for the complement subcomponent Clq on immunoglobulin G involves the last two (C-terminal) beta-strands of the C gamma 2 domain. This region contains a large number of accessible and highly conserved charged residues and charge is postulated as an important component of the Clq-IgG interaction. The conclusions are reached on the basis of accessibility and sequence conservation analyses of C gamma 2 amino acid residues, the use of specific inhibitors and chemical modification studies.