Ocular sarcoidosis: a multivariate analysis of risk factors
Mochizuki, M.; Ohara, K.; Izawa, Y.; Nagataki, S.
Nippon Ganka Gakkai Zasshi 84(2): 113-117
1980
ISSN/ISBN: 0029-0203 PMID: 7377044 Document Number: 166950
A multivariate analysis for ocular manifestations of sarcoidosis was performed on 53 patients suspected of having the disease. The diagnosis of sarcoidosis was confirmed in 33 cases on the basis of radiologic and laboratory tests and biopsy. A discriminant function was determined to separate the 33 cases from the remaining 20 cases where the causes of ocular involvements were unknown. The variables were mutton-fat keratic precipitates, iris nodules, nodules in the trabeculum, peripheral anterior synechiae, string of pearls, perivasculitis and candle wax spots. The above 7 manifestations were labeled 0 for not present and 1 for present, over a 6-mo. follow up period. The cases with only 1 eye involved were labeled 0 for unilateral and the cases with bilateral involvements were expressed as 1. Discriminant coefficients for bilateral involvement and peripheral anterior synechia were 1.28 and 0.83, respectively; these values were significant for descrimination between the 2 groups, i.e., the sarcoidosis cases and the cases with unknown cause. On the above bases, 28 cases (85%) from the sarcoidosis group or 16 cases (80%) from the non-sarcoidosis group were correctly diagnosed. The peripheral anterior synechiae with bilateral ocular involvement is important in the diagnosis of ocular sarcoidosis.