In vitro thrombogenicity tests of factor IX concentrates. I. A survey of available assays
Prowse, C.V.; Chirnside, A.; Elton, R.A.
Thrombosis and Haemostasis 42(5): 1355-1367
1980
ISSN/ISBN: 0340-6245 PMID: 6768149 Document Number: 166427
Various factor IX concentrates were examined in a number of in vitro tests of thrombogenicity. Some tests are apparently superfluous as in concentrates with activity in any of these tests activation is revealed by a combination of the non-activated partial thromboplastin time, the thrombin (or Xa) generation time and factor VIII inhibitor bypassing activity tests . Assay of individual coagulant enzymes revealed that most concentrates contained more factor IXa than Xa. A small number of concentrates, chiefly those that had been purposefully activated, contained appreciable amounts of either enzyme.