The complement system in hemolytic-uremic syndrome in childhood
Monnens, L.; Molenaar, J.; Lambert, P.H.; Proesmans, W.; van Munster, P.
Clinical Nephrology 13(4): 168-171
1980
ISSN/ISBN: 0301-0430 PMID: 7379368 Document Number: 166031
A dynamic estimation of the complement system was obtained by immunochemical estimation of C3, C4, C5, C1q, C3b + C3c, C3d, Ba in children with hemolytic-uremic syndrome. The presence of increased breakdown products of C3 (C3b + C3c, C3d) and of factor B (Ba) suggests an activation of the complement system possibly by the alternative pathway. No definite explanation for these complement abnormalities can be given.